SH3RF1 and ARHGEF15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SH3RF1	ARHGEF15
Description		SH3 domain containing ring finger 1	Rho guanine nucleotide exchange factor 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Dendrite
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Neuron Migration Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Activation Of GTPase Activity Negative Regulation Of Synapse Maturation
Pathways		RHOV GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Bipolar disorder ( 28115744) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) Platelet distribution width ( 32888494) Total cholesterol levels ( 30275531) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	14 interacting genes: C11orf49 CDC42 CEP55 DNAJC5 EPHA4 ESR1 ESRRG GORASP2 LASP1 MOB4 PIN1 PRKG1 RHOA SH3RF1
Entrez ID		57630	22899
HPRD ID		15335	10535
Ensembl ID		ENSG00000154447	ENSG00000198844
Uniprot IDs		Q7Z6J0	A0A0S2Z547 O94989
PDB IDs
Enriched GO Terms of Interacting Partners?
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