PTGIS and BTF3

		PTGIS	BTF3
Description		prostaglandin I2 synthase	basic transcription factor 3
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GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane	Nucleus Cytosol Nascent Polypeptide-associated Complex Polysomal Ribosome
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Hydroperoxy Icosatetraenoate Dehydratase Activity	RNA Binding Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Cyclooxygenase Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis	In Utero Embryonic Development Transcription By RNA Polymerase II Protein Transport
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)	Eyebrow thickness ( 26926045) Monobrow thickness ( 26926045)
Interacting Genes		10 interacting genes: APP ARFGEF2 BTF3 GMFG GNAS LTB4R2 PKHD1 PTGS1 PTGS2 TMSB4XP6	14 interacting genes: APP CDC42 CSNK2B IFTAP MED21 NAA40 NMT2 NOTO POLR2B PTGIS TXLNA TXLNB USP16 ZDHHC17
Entrez ID		5740	689
HPRD ID		09046	03966
Ensembl ID		ENSG00000124212	ENSG00000145741
Uniprot IDs		Q16647	P20290
PDB IDs		2IAG 3B6H	3LKX 3MCB
Enriched GO Terms of Interacting Partners?
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