TTYH1 and GPR37

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		TTYH1	GPR37
Description		tweety family member 1	G protein-coupled receptor 37
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Smooth Endoplasmic Reticulum Membrane Chloride Channel Complex	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Intracellular Calcium Activated Chloride Channel Activity Chloride Channel Activity Iron Ion Transmembrane Transporter Activity Protein Binding Volume-sensitive Chloride Channel Activity	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Chloride Transport Iron Ion Transport Cell Adhesion Ion Transmembrane Transport Iron Ion Transmembrane Transport	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Idiopathic pulmonary fibrosis ( 29066090)	Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 32341527 26237428) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CCR9 DRD2 GPR37 HTR6 TMEM60 USP54	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		57348	2861
HPRD ID		12043	03992
Ensembl ID		ENSG00000167614	ENSG00000170775
Uniprot IDs		Q9H313	O15354
PDB IDs
Enriched GO Terms of Interacting Partners?
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