RCN3 and STAT6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		RCN3	STAT6
Description		reticulocalbin 3	signal transducer and activator of transcription 6
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Intracellular Membrane-bounded Organelle	Chromatin Nucleoplasm Cytosol Membrane Raft
	Molecular Function	Calcium Ion Binding Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Protein Secretion Positive Regulation Of Peptidase Activity Protein Transport Collagen Biosynthetic Process ERAD Pathway Surfactant Homeostasis Regulation Of Protein Kinase B Signaling Phospholipid Homeostasis Lung Epithelium Development	Negative Regulation Of Transcription By RNA Polymerase II T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgE Isotypes Growth Hormone Receptor Signaling Pathway Via JAK-STAT Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Reactive Nitrogen Species
Pathways			Downstream signal transduction STAT6-mediated induction of chemokines Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Fructosamine levels ( 29844224) Height ( 31562340) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Mean spheric corpuscular volume ( 32888494) Schizophrenia ( 25056061) Total glycated albumin levels ( 29844224)	Adult asthma ( 30787307) Alcohol consumption ( 31358974) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 25407941) Eosinophilic esophagitis (pediatric) ( 20208534) Familial lung cancer ( 29924316) Headache ( 29397368) Height ( 31562340) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (adrenergics, inhalants) ( 31015401) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Migraine ( 27322543) Migraine without aura ( 27322543) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		13 interacting genes: CCDC103 HID1 KLHL42 MBD3 MKNK1 MYO15B NAA10 PACRGL PCSK6 PRUNE2 STAT6 SUFU ZNF417	39 interacting genes: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 FBXO7 H3C14 IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRIM1 PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92
Entrez ID		57333	6778
HPRD ID		17962	03302
Ensembl ID		ENSG00000142552	ENSG00000166888
Uniprot IDs		Q96D15	A8K4S9 B4DQB3 H0YJH6 P42226
PDB IDs			1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX
Enriched GO Terms of Interacting Partners?
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