PTCH1 and IHH

Number of citations of the paper that reports this interaction (PubMedID 9811851)
63

Data Source:
HPRD (in vivo)

		PTCH1	IHH
Description		patched 1	Indian hedgehog signaling molecule
Image
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Caveola Postsynaptic Density Integral Component Of Membrane Midbody Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Dendritic Growth Cone Axonal Growth Cone Apical Part Of Cell Perinuclear Region Of Cytoplasm Ciliary Membrane	Extracellular Space Plasma Membrane Extracellular Matrix
	Molecular Function	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein-containing Complex Binding Hedgehog Family Protein Binding	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Cell Fate Determination Neural Tube Closure Heart Morphogenesis Smoothened Signaling Pathway Regulation Of Mitotic Cell Cycle Brain Development Regulation Of Smoothened Signaling Pathway Response To Xenobiotic Stimulus Response To Mechanical Stimulus Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Epidermal Cell Fate Specification Response To Chlorate Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Prostate Gland Development Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Multicellular Organism Growth Glucose Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Keratinocyte Proliferation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Embryonic Organ Development Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Commissural Neuron Axon Guidance Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Protein Localization To Plasma Membrane Liver Regeneration	Skeletal System Development Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Proteoglycan Metabolic Process Smoothened Signaling Pathway Cell-cell Signaling Response To Mechanical Stimulus Embryonic Pattern Specification Regulation Of Gene Expression Intein-mediated Protein Splicing Protein Autoprocessing Vitelline Membrane Formation Pancreas Development Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion Liver Regeneration
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Hedgehog 'on' state Activation of SMO	Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np RUNX2 regulates chondrocyte maturation
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adventurousness ( 30643258) Alanine aminotransferase levels ( 33547301) Anxiety ( 33859377) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 26733130) Bone mineral density (spine) ( 26733130) Brain morphology (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Dental caries (decayed, missing and filled teeth) ( 31533690) Feeling hurt ( 29500382) Feeling worry ( 29500382) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 25429064 31562340 18391952) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Infant length ( 25281659) Kidney volume ( 34128465) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Macular thickness ( 30535121) Monobrow ( 27182965) Neurociticism ( 29500382) Nonsyndromic cleft lip with cleft palate ( 28232668) Offspring birth weight ( 31043758) Optic disc size ( 31809533) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)	Height ( 20881960 31562340 18391951 18391952 20189936) Waist circumference adjusted for body mass index ( 26785701)
Interacting Genes		21 interacting genes: APPBP2 ATG101 ATM CCNB1 CD200R1 CD74 CD79A CDK1 CREB3 DHH FAM209A HIBADH HIPK2 IHH SHH SIGLEC12 SMO STOM TMPRSS2 TSPAN8 YAP1	4 interacting genes: HHIP PTCH1 PTCH2 RHOD
Entrez ID		5727	3549
HPRD ID		03200	02839
Ensembl ID		ENSG00000185920	ENSG00000163501
Uniprot IDs		Q13635	Q14623
PDB IDs		6DMB 6DMO 6DMY 6E1H 6N7G 6N7H 6N7K 6OEU 6OEV 6RMG 6RTW 6RTX 6RTY 6RVC 6RVD	3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P
Enriched GO Terms of Interacting Partners?
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