PSPH and ITGB8

		PSPH	ITGB8
Description		phosphoserine phosphatase	integrin subunit beta 8
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GO Annotations	Cellular Component	Cytoplasm Cytosol Neuron Projection	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta8 Complex Extracellular Exosome
	Molecular Function	Magnesium Ion Binding L-phosphoserine Phosphatase Activity Identical Protein Binding Protein Homodimerization Activity	Integrin Binding Signaling Receptor Activity Extracellular Matrix Protein Binding
	Biological Process	In Utero Embryonic Development L-serine Metabolic Process L-serine Biosynthetic Process Response To Mechanical Stimulus Dephosphorylation Response To Nutrient Levels Response To Testosterone	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Regulation Of Transforming Growth Factor Beta Activation
Pathways		Serine biosynthesis	Molecules associated with elastic fibres Integrin cell surface interactions
Drugs		Zinc 3-Phosphono-D-alanine Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Estimated glomerular filtration rate ( 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glycine levels ( 31070104 30837465) Macular telangiectasia type 2 ( 28250457 33654266) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma homocysteine levels (post-methionine load test) ( 24651765) Serum metabolite levels ( 33031748)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 34103634 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Chronic obstructive pulmonary disease ( 30804561) Eosinophil counts ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Type 1 diabetes ( 34012112) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: ATXN1 ITGB8	11 interacting genes: CHN2 HOXA1 ITGAV PSPH RAPGEF5 RRAGD SH2D3A SP4 TGFB1 TOMM7 VTN
Entrez ID		5723	3696
HPRD ID		01406	05001
Ensembl ID		ENSG00000146733	ENSG00000105855
Uniprot IDs		A0A024RDL3 P78330	P26012 Q9BUG9
PDB IDs		1L8L 1L8O 1NNL 6HYJ 6HYY 6Q6J	6DJP 6OM1 6OM2 6UJA 6UJB 6UJC
Enriched GO Terms of Interacting Partners?
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