DDX24 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		DDX24	POLA2
Description		DEAD-box helicase 24	DNA polymerase alpha 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Membrane	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	RNA Binding RNA Helicase Activity ATP Binding ATP Hydrolysis Activity	Molecular_function DNA Binding Protein Binding
	Biological Process	RNA Metabolic Process	DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs			Dacarbazine
Diseases
GWAS		Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Post bronchodilator FEV1/FVC ratio ( 26634245)	Acne (severe) ( 24927181) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		34 interacting genes: BCS1L BRCA1 CSNK2A1 EIF3E EP300 FADD GIT1 GLRA2 HSP90AB1 HSPA5 IDO1 ITGB3BP LMNA MDM2 MKS1 MRPL4 NRXN2 PAFAH1B3 PIN1 POLA2 PRF1 PTEN PTPN23 RAE1 SPACA9 SPTAN1 TERF1 TERF2 TERF2IP TMEM9B TPI1 TRDMT1 UBE2I VDAC3	41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2
Entrez ID		57062	23649
HPRD ID		05860	10160
Ensembl ID		ENSG00000089737	ENSG00000014138
Uniprot IDs		Q9GZR7	Q14181
PDB IDs			2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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