PAK6 and SPG11

		PAK6	SPG11
Description		p21 (RAC1) activated kinase 6	SPG11 vesicle trafficking associated, spatacsin
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Cell Junction	Nucleolus Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension	Chemical Synaptic Transmission Axo-dendritic Transport Synaptic Vesicle Transport Axon Extension Phagosome-lysosome Fusion Involved In Apoptotic Cell Clearance Walking Behavior
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Anti-Toxoplasma gondii IgG seropositivity ( 30610941) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		28 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1	2 interacting genes: PAK6 SERTAD3
Entrez ID		56924	80208
HPRD ID		06426	07963
Ensembl ID		ENSG00000137843	ENSG00000104133
Uniprot IDs		A0A024R9Q4 Q9NQU5	Q96JI7
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?