EXOSC5 and SHISA6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EXOSC5	SHISA6
Description		exosome component 5	shisa family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Postsynaptic Density AMPA Glutamate Receptor Complex Dendritic Spine Membrane Postsynaptic Membrane Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Protein Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Spermatogenesis Wnt Signaling Pathway Regulation Of Short-term Neuronal Synaptic Plasticity Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Activity Postsynaptic Neurotransmitter Receptor Diffusion Trapping Excitatory Chemical Synaptic Transmission Regulation Of AMPA Glutamate Receptor Clustering Regulation Of AMPA Receptor Activity
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Copper levels ( 26025379) Daytime sleep phenotypes ( 27126917) Myopia ( 27182965) Obesity-related traits ( 23251661) Refractive error ( 23396134 32231278) Seborrheic dermatitis ( 29203360) Sleep duration (short sleep) ( 30846698) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		83 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HAMP HOXC4 IKZF3 KCTD13 KIAA1217 KMT2A KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PAF1 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PRODH2 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792	29 interacting genes: ANKS1A ARMC7 BAG3 CARD9 CCDC57 CDKN1A CIAO1 CTBP2 CYSRT1 EXOSC5 FBLIM1 GOLGA2 HSF2BP KAT5 KIF9 KIFC3 KRT31 KRTAP3-3 LMO3 NEDD4 OIP5 PFDN5 PLEKHG4 SMARCD1 TLE5 TRIP6 TSSK3 TTC19 UBASH3A
Entrez ID		56915	388336
HPRD ID		16222	13507
Ensembl ID		ENSG00000077348	ENSG00000188803
Uniprot IDs		Q9NQT4	Q6ZSJ9
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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