METTL3 and EIF3M

Number of citations of the paper that reports this interaction (PubMedID 30232453)
165

Data Source:
BioGRID (pull down)

		METTL3	EIF3M
Description		methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	eukaryotic translation initiation factor 3 subunit M
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	MRNA (N6-adenosine)-methyltransferase Activity MRNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity MRNA (2'-O-methyladenosine-N6-)-methyltransferase Activity Protein Heterodimerization Activity S-adenosyl-L-methionine Binding	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Methylation Adenosine To Inosine Editing MRNA Processing MRNA Catabolic Process Cellular Response To DNA Damage Stimulus Spermatogenesis Circadian Rhythm Dosage Compensation By Inactivation Of X Chromosome Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Primary MiRNA Processing Cellular Response To UV Gliogenesis Innate Immune Response Regulation Of T Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Notch Signaling Pathway Oogenesis Regulation Of Meiotic Cell Cycle Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization MRNA Methylation Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Cap-independent Translational Initiation Primary MiRNA Methylation	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translational Initiation
Pathways		Processing of Capped Intron-Containing Pre-mRNA	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Response to Homoharringtonine (cytotoxicity) ( 25628645)	Menopause (age at onset) ( 26414677) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		9 interacting genes: EIF3G EIF3I EIF3J EIF3M MAPK1 MAPK14 MAPK8 MTDH USP5	10 interacting genes: ABI3 APP EIF3F EXOSC10 HSPB1 METTL3 SRPK1 TRIML2 ZMYND10 ZNF783
Entrez ID		56339	10480
HPRD ID		14389	09969
Ensembl ID		ENSG00000165819	ENSG00000149100
Uniprot IDs		Q86U44	Q7L2H7
PDB IDs		5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 5YZ9 6TTP 6TTT 6TTV 6TTW 6TTX 6TU1 6Y4G 7ACD	3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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