PROX1 and LBH

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PROX1	LBH
Description		prospero homeobox 1	LBH regulator of WNT signaling pathway
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding DNA Binding Domain Binding LBD Domain Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Determination Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Lens Development In Camera-type Eye Hepatocyte Cell Migration Regulation Of Transcription By RNA Polymerase II Brain Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Lens Placode Formation Involved In Camera-type Eye Formation Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Population Maintenance Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation	Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Somatic Stem Cell Division Positive Regulation Of Mammary Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Birth weight ( 31043758) Blood glucose levels ( 31928498) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679) Glycemic traits (pleiotropy) ( 31021400) Hematocrit ( 29403010 32888494 27863252) Hemoglobin ( 29403010 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) HIV-1 progression ( 20064070) Homeostasis model assessment of beta-cell function ( 20081858) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monoclonal gammopathy of undetermined significance ( 30737484) Obesity ( 23818313) Pancreas volume ( 34128465) Red blood cell count ( 29403010 32888494 27863252) Refractive error ( 32231278) Rheumatic heart disease ( 34106200) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 25961943) Type 2 diabetes ( 28566273 22885922 24509480 29358691 30297969 32499647) Type 2 diabetes (age of onset) ( 28060188)	Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) HDL cholesterol levels ( 32203549) Height ( 18391951) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 33272962 28714469) vWF and FVIII levels ( 21810271) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NEK2 NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3	1 interacting genes: PROX1
Entrez ID		5629	81606
HPRD ID		03330	13965
Ensembl ID		ENSG00000117707	ENSG00000213626
Uniprot IDs		Q92786	Q53QV2
PDB IDs		2LMD
Enriched GO Terms of Interacting Partners?
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