PROC and GGCX

Number of citations of the paper that reports this interaction (PubMedID 1498334)
8

Data Source:
HPRD (in vitro)

		PROC	GGCX
Description		protein C, inactivator of coagulation factors Va and VIIIa	gamma-glutamyl carboxylase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Gamma-glutamyl Carboxylase Activity Vitamin Binding
	Biological Process	Proteolysis Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9
Drugs		Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human	Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases
GWAS		Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)	Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)
Interacting Genes		17 interacting genes: CFLAR CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 NGLY1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	14 interacting genes: ARFGAP1 ATP2C1 BGLAP CD8A F10 F2 F7 F9 FXN PDCD5 PPM1G PROC SRPK2 ST3GAL4
Entrez ID		5624	2677
HPRD ID		01466	00665
Ensembl ID		ENSG00000115718	ENSG00000115486
Uniprot IDs		P04070	P38435
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C
Enriched GO Terms of Interacting Partners?
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