MAP2K2 and RIPOR2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		MAP2K2	RIPOR2
Description		mitogen-activated protein kinase kinase 2	RHO family interacting cell polarization regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Cytoskeleton Apical Plasma Membrane Filopodium Stereocilium Stereocilium Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Protein Binding 14-3-3 Protein Binding
	Biological Process	MAPK Cascade Peptidyl-tyrosine Phosphorylation Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Early Endosome To Late Endosome Transport	Chemotaxis Cell Adhesion Negative Regulation Of Cell Adhesion Sensory Perception Of Sound Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Myoblast Differentiation Skeletal Muscle Fiber Development Positive Regulation Of Filopodium Assembly Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Myoblast Fusion Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Cellular Response To Chemokine Regulation Of Establishment Of Cell Polarity Positive Regulation Of Neutrophil Extravasation Negative Regulation Of T Cell Migration Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		Bosutinib Trametinib Selumetinib Binimetinib Fostamatinib
Diseases
GWAS		Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Height ( 29782485) Lymphocyte counts ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		20 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D HNRNPK LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 MOS RAF1 RGS12 RIPOR2 ZNF207	6 interacting genes: MAP2K2 MTNR1B PER1 RHOA RHOC YWHAG
Entrez ID		5605	9750
HPRD ID		03164	12881
Ensembl ID		ENSG00000126934	ENSG00000111913
Uniprot IDs		P36507	A0A024QZY9 A0A024R028 A0A2R8Y7B3 A0A2R8YEE0 B7Z5J9 B7Z6D6 B7Z6U4 F5GX51 F5H029 Q9Y4F9
PDB IDs		1S9I 4H3Q
Enriched GO Terms of Interacting Partners?
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