DEFB103B and TMPRSS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DEFB103B	TMPRSS2
Description		defensin beta 103B	transmembrane serine protease 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding CCR6 Chemokine Receptor Binding Chemoattractant Activity	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Killing Of Cells Of Other Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Killing By Host Of Symbiont Cells Cell Chemotaxis	Proteolysis Endocytosis Protein Autoprocessing Positive Regulation Of Viral Entry Into Host Cell
Pathways		Beta defensins Defensins	Attachment and Entry Attachment and Entry Attachment and Entry
Drugs			Camostat
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		12 interacting genes: AQP6 B3GALT5 CCR6 EBP ERGIC3 ODF4 SCN3B SPATA31A7 SSMEM1 TMEM14B TMEM31 TMPRSS2	60 interacting genes: ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF TRAPPC10 UPK2 VAMP5 ZFPL1
Entrez ID		55894	7113
HPRD ID		05968	03637
Ensembl ID		ENSG00000177243	ENSG00000184012
Uniprot IDs		P81534	O15393
PDB IDs		1KJ6
Enriched GO Terms of Interacting Partners?
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