PRKCSH and GBA3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PRKCSH	GBA3
Description		protein kinase C substrate 80K-H	glucosylceramidase beta 3 (gene/pseudogene)
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Glucosidase II Complex Intracellular Membrane-bounded Organelle	Cytosol Catalytic Complex
	Molecular Function	Protein Kinase C Binding Calcium Ion Binding Protein Binding Transmembrane Transporter Binding Phosphoprotein Binding	Galactosylceramidase Activity Glucosylceramidase Activity Beta-galactosidase Activity Protein Binding Beta-glucosidase Activity Glycosylceramidase Activity Scopolin Beta-glucosidase Activity
	Biological Process	Liver Development N-glycan Processing Intracellular Signal Transduction	Glucosylceramide Catabolic Process Galactosylceramide Catabolic Process Glycosphingolipid Metabolic Process Glycoside Catabolic Process Glycosylceramide Catabolic Process Protein Stabilization Cellular Oligosaccharide Catabolic Process Beta-glucoside Catabolic Process Positive Regulation Of Exo-alpha-sialidase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Post-translational protein phosphorylation Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein	Glycosphingolipid metabolism
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658) Serum metabolite levels (CMS) ( 31636271)	Ankylosing spondylitis ( 30946743) Anti-saccade response ( 29064472) Blood metabolite levels ( 24816252) Fasting glucose ( 33381925) Manganese levels ( 26025379) Metabolite levels ( 23823483) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Rosacea symptom severity ( 29771307) Serum metabolite levels ( 33031748 23093944) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		12 interacting genes: ARL4D CANX ESR1 FXR1 GANAB GBA3 GET4 PTPRC RGS2 RPS6 SMARCA4 VDR	2 interacting genes: PRKCSH TNS2
Entrez ID		5589	57733
HPRD ID		03518	09428
Ensembl ID		ENSG00000130175	ENSG00000249948
Uniprot IDs		B4DJQ5 K7ELL7 P14314	A8K9N1 B7Z536 Q9H227
PDB IDs			2E9L 2E9M 2JFE 2ZOX 3VKK
Enriched GO Terms of Interacting Partners?
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