HR and RARA

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		HR	RARA
Description		HR lysine demethylase and nuclear receptor corepressor	retinoic acid receptor alpha
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cell Surface Actin Cytoskeleton Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coregulator Activity Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3-methyl-lysine-9 Demethylase Activity Metal Ion Binding	Translation Repressor Activity, MRNA Regulatory Element Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Chromatin DNA Binding Histone Deacetylase Binding Protein Kinase B Binding Retinoic Acid-responsive Element Binding MRNA 5'-UTR Binding Protein Kinase A Binding Alpha-actinin Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Histone H3-K9 Demethylation	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Neural Tube Closure Liver Development Glandular Epithelial Cell Development Growth Plate Cartilage Development Protein Phosphorylation Signal Transduction Germ Cell Development Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Negative Regulation Of Translation Hippocampus Development Cell Differentiation Prostate Gland Development Negative Regulation Of Granulocyte Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Response To Estradiol Response To Retinoic Acid Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Response To Vitamin A Response To Cytokine Multicellular Organism Growth Regulation Of Apoptotic Process Apoptotic Cell Clearance Response To Ethanol Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Ventricular Cardiac Muscle Cell Differentiation Sertoli Cell Fate Commitment Limb Development Face Development Trachea Cartilage Development Chondroblast Differentiation Negative Regulation Of Cartilage Development Cellular Response To Lipopolysaccharide Cellular Response To Estrogen Stimulus
Pathways			Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin Tamibarotene LGD-1550 Trifarotene
Diseases
GWAS		Obesity-related traits ( 23251661)	Asthma ( 31619474)
Interacting Genes		36 interacting genes: AMMECR1 ATP23 C11orf1 C19orf54 CNFN CYSRT1 FAM168A GEMIN4 HDAC1 HDAC3 HDAC5 HMGB1 HOXA1 INCA1 KLHL20 KRTAP11-1 KRTAP13-2 KRTAP15-1 KRTAP3-1 KRTAP3-3 KRTAP6-3 MGAT5B PLA2G10 PRKCA RARA RARB RBP3 SH2D4A SPAG8 SPRY3 TBL1X TRIM27 TSC1 VDR YPEL3 ZMYND12	98 interacting genes: ACTN4 AKT1 ALOX15B ALX1 ARID1A ARID5A ARNTL BAG1 BBS4 BTG1 CCND3 CCNDBP1 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FGFR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MCRS1 MDM2 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2C1 NR2E3 NR3C1 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PLEKHF2 PML PNRC2 POU2F1 PPARG PRAME PRDX6 PRKCA PSMC5 RXRA RXRB RXRG S100A3 SIRT1 SMARCD3 SNW1 SP1 SPEN SRC SRF STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIB3 TRIM24 TRIP4 TUBG1 UBE3A UBQLN1 USP7 ZBTB16
Entrez ID		55806	5914
HPRD ID		03808	06769
Ensembl ID		ENSG00000168453	ENSG00000131759
Uniprot IDs		O43593	A8K840 A8MUP8 F1D8N9 P10276 Q6I9R7
PDB IDs			1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM 5K13 6XWG
Enriched GO Terms of Interacting Partners?
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