DOK4 and PAX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DOK4	PAX8
Description		docking protein 4	paired box 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Positive Regulation Of MAPK Cascade	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Ventricular Septum Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Sulfur Compound Metabolic Process Central Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Pronephros Development Anatomical Structure Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion
Pathways		RET signaling
Drugs
Diseases
GWAS			Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Creatinine levels ( 29403010) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Lymphocyte counts ( 27863252) Mucinous ovarian carcinoma ( 26075790) Optic disc size ( 31809533) Renal function-related traits (BUN) ( 22797727) Sleep duration ( 27992416 27494321 25469926) Sleep duration (long sleep) ( 30846698) Sleep duration (oversleepers vs undersleepers) ( 27494321) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416) Urate levels ( 31578528) Weight ( 28552196)
Interacting Genes		21 interacting genes: CRK EGFR ERBB2 FYN IGF1R INCA1 INSR LIX1 MAPRE3 OLIG1 OPRM1 PAX8 PFDN5 PTK2 RASA1 RBP7 RET RHOU SRC STAT2 TEK	23 interacting genes: ANXA7 AURKA CDK3 CHUK CXCL9 DOK4 EP300 GCM2 HOXC8 HOXC9 ID2 LONRF1 NKX2-1 PKM POU2AF1 SAE1 SERINC1 SKP2 SLIT2 SMAD3 SS18L1 TLE5 WBP2
Entrez ID		55715	7849
HPRD ID		16316	01335
Ensembl ID		ENSG00000125170	ENSG00000125618
Uniprot IDs		A0A024R6S2 H3BQ19 Q8TEW6	A0A024R4X8 A0A024R524 Q06710 R9W7C9
PDB IDs			2K27
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?