FEM1A and MALT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FEM1A	MALT1
Description		fem-1 homolog A	MALT1 paracaspase
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Mitochondrion Cytosol Cul2-RING Ubiquitin Ligase Complex	Fibrillar Center Polkadots Nucleus Cytoplasm Cytosol CBM Complex Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding EP4 Subtype Prostaglandin E2 Receptor Binding Ubiquitin Ligase-substrate Adaptor Activity	Protease Binding Endopeptidase Activity Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Protein Binding Peptidase Activity Kinase Activator Activity Identical Protein Binding Protein Self-association
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	B-1 B Cell Differentiation Positive Regulation Of T Cell Cytokine Production Proteolysis Defense Response Activation Of NF-kappaB-inducing Kinase Activity Response To Fungus Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-2 Production T Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nuclear Export Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of T-helper 17 Cell Differentiation
Pathways		Neddylation	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway
Drugs
Diseases
GWAS		Height ( 31562340)	Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 21833088)
Interacting Genes		11 interacting genes: ACAA1 GOLGA6L9 INCA1 KIFC3 MALT1 MYOM3 NDUFAB1 OGFOD1 PPM1F PTGER4 WWOX	16 interacting genes: BCL10 CARM1 FEM1A FEM1C KDM1A PRMT6 RAB8A RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBC UBE2N UBE2V2 USP2
Entrez ID		55527	10892
HPRD ID		16888	06892
Ensembl ID		ENSG00000141965	ENSG00000172175
Uniprot IDs		Q9BSK4	A8K5S1 Q9UDY8
PDB IDs			2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1P 4I1R 6F7I 6GK2 6H4A 6YN8 6YN9 7A41 7AK0 7AK1
Enriched GO Terms of Interacting Partners?
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