HJURP and CENPA

Number of citations of the paper that reports this interaction (PubMedID 26496610)
430

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology)

		HJURP	CENPA
Description		Holliday junction recognition protein	centromere protein A
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleoplasm Nucleolus Mitochondrion	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleosome Inner Kinetochore Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol
	Molecular Function	DNA Binding Protein Binding Histone Binding Identical Protein Binding	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Regulation Of Protein-containing Complex Assembly Regulation Of DNA Binding	Establishment Of Mitotic Spindle Orientation Mitotic Cytokinesis Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Hair greying ( 26926045) Headache ( 29397368) Migraine ( 27322543) Migraine without aura ( 27322543) Total bilirubin levels in HIV-1 infection ( 25884002)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: CENPA H4C1 IMMT MIS18A OIP5 STT3A	11 interacting genes: AURKB AURKC CDKN2A CUL4A DIAPH1 DIAPH2 H3C3 H4C6 HJURP PARP1 PARP2
Entrez ID		55355	1058
HPRD ID		10912	00313
Ensembl ID		ENSG00000123485	ENSG00000115163
Uniprot IDs		Q8NCD3	P49450
PDB IDs		3R45	3AN2 3NQJ 3NQU 3R45 3WTP 5CVD 5Z23 6BUZ 6C0W 6E0C 6E0P 6KDQ 6KDS 6L49 6MUO 6MUP 6O1D 6SE0 6SE6 6SEE 6SEF 6SEG 6TEM 7D20
Enriched GO Terms of Interacting Partners?
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