DRAM1 and LRRC4C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DRAM1	LRRC4C
Description		DNA damage regulated autophagy modulator 1	leucine rich repeat containing 4C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Integral Component Of Membrane	Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding	Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Autophagy Apoptotic Process Regulation Of Autophagy	Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Synaptic Membrane Adhesion
Pathways
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 30823506) Shigella-associated diarrhea ( 33649051) Systemic lupus erythematosus ( 23273568 33272962)	Blood protein levels ( 30072576) Cerebellum cortex volume ( 31530798) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cerebrospinal fluid p-tau levels ( 29274321) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) General risk tolerance (MTAG) ( 30643258) High myopia ( 31816047) Iris color (L* coordinate) ( 30895295) Mastocytosis (KIT D816V positive) ( 33421400) Mosquito bite size ( 28199695) Myopia ( 27182965) Osteoporosis-related phenotypes ( 20548944) Pediatric central nervous system tumors (early onset)(pleiotropy) ( 33226468) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Survival in colorectal cancer ( 26586795) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		10 interacting genes: APP C1orf21 CD164L2 CLRN1 CREB3 EVI2B GPR42 LRRC4C MS4A7 TIMMDC1	29 interacting genes: AGTRAP BDKRB1 BMP10 BRICD5 CLDN19 CLEC1A CLEC4G CMTM5 CREB3L4 DOLK DRAM1 EMP3 GJB2 LEPROTL1 LHFPL5 MIP NTNG1 PGAP2 PLP2 SERTM1 SMIM1 SNAP47 STX5 TRAF6 TWSG1 VEZT VSTM1 WHRN YIPF6
Entrez ID		55332	57689
HPRD ID		07743	12303
Ensembl ID		ENSG00000136048	ENSG00000148948
Uniprot IDs		A0A024RBF9 Q8N682	Q4JIV9 Q4JIW0 Q9HCJ2
PDB IDs			3ZYJ
Enriched GO Terms of Interacting Partners?
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