VRTN and C9orf72

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		VRTN	C9orf72
Description		vertebrae development associated	C9orf72-SMCR8 complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin	P-body Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytosol Cytoplasmic Stress Granule Dendrite Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Perikaryon Intracellular Membrane-bounded Organelle Axonal Growth Cone Main Axon Flemming Body
	Molecular Function	Transposase Activity Protein Binding Sequence-specific DNA Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Transposition, DNA-mediated Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Stress Granule Assembly Axon Extension Regulation Of Catalytic Activity Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Negative Regulation Of GTP Binding Regulation Of Autophagosome Assembly
Pathways
Drugs
Diseases
GWAS		FEV1 ( 30804560) Lung function (FVC) ( 30804560) Refractive error ( 32231278)	Amyotrophic lateral sclerosis ( 30976013 25442119 29566793 22959728 27455348 19734901 20801718 24931836) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)
Interacting Genes		10 interacting genes: C9orf72 CTBP2 EIF4A3 FAM90A1 POLR3C RAB2B RAB3A RAB3B RAB3C RAB3D	14 interacting genes: APP COIL CRX EIF2B2 HMG20A NMI POP7 REL SMCR8 SMN1 SRPK1 SYN3 TRIM73 VRTN
Entrez ID		55237	203228
HPRD ID		16593	12975
Ensembl ID		ENSG00000133980	ENSG00000147894
Uniprot IDs		Q9H8Y1	Q96LT7
PDB IDs			6LT0 6V4U
Enriched GO Terms of Interacting Partners?
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