DARS2 and AIMP2

Number of citations of the paper that reports this interaction (PubMedID 9878398)
57

Data Source:
BioGRID (two hybrid)

		DARS2	AIMP2
Description		aspartyl-tRNA synthetase 2, mitochondrial	aminoacyl tRNA synthetase complex interacting multifunctional protein 2
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Nucleus Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity	Protein Binding Molecular Adaptor Activity
	Biological Process	Aspartyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Translation Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Type II Pneumocyte Differentiation Protein-containing Complex Assembly Positive Regulation Of Neuron Death Positive Regulation Of Aminoacyl-tRNA Ligase Activity
Pathways		Mitochondrial tRNA aminoacylation	Selenoamino acid metabolism Cytosolic tRNA aminoacylation
Drugs		Aspartic acid
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		15 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50	105 interacting genes: ACTB AIMP1 APP BCAS2 BEX3 BLOC1S4 BRME1 BYSL C1orf216 CBY2 CCDC153 CEP126 CHD3 DARS1 DARS2 DEAF1 DISC1 DSN1 EPRS1 EPS8 EXOC8 FGB FHL3 FUBP1 GYS1 HSPA1A HSPA4 ICE1 KARS1 KDR KLC2 KRT31 KRT33B KRT34 KRT36 LMO2 LMO3 LNX1 LUC7L2 MAD1L1 MATR3 MCF2L MIR106A MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR15A MIR18A MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR34A MIR34B MIR34C MIR429 MIR451A MIR7-1 MIR7-2 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I MIS18A NDEL1 NECAB2 NTAQ1 PFDN6 PLEKHF2 PPP2R1A PRKAA2 PRKN PSME1 RABEP1 SBK3 SLU7 SMURF2 SPATA18 TANK TCP11 TERF2IP TEX12 TFIP11 TRAF2 TRMT2A ZC3H12A ZGPAT
Entrez ID		55157	7965
HPRD ID		07677	02915
Ensembl ID		ENSG00000117593	ENSG00000106305
Uniprot IDs		Q6PI48 Q9H9J7	A0A024QZY1 A8MU58 Q13155
PDB IDs		4AH6	4DPG 4YCU 4YCW 5A1N 5A34 5A5H 5Y6L 6ILD 6IY6 6JPV 6K39
Enriched GO Terms of Interacting Partners?
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