CDCA8 and NEK3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CDCA8	NEK3
Description		cell division cycle associated 8	NIMA related kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleoplasm Nucleolus Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone	Nucleus Cytoplasm Axon
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Metaphase Plate Congression Chromosome Organization Cell Division	Mitotic Cell Cycle Protein Phosphorylation Establishment Of Cell Polarity Neuron Projection Morphogenesis Cell Division Regulation Of Tubulin Deacetylation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		26 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277	6 interacting genes: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2
Entrez ID		55143	4752
HPRD ID		13017	04954
Ensembl ID		ENSG00000134690	ENSG00000136098
Uniprot IDs		Q53HL2	P51956 Q6ZN64
PDB IDs		2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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