SLFN12 and GSDMB

		SLFN12	GSDMB
Description		schlafen family member 12	gasdermin B
Image		No pdb structure
GO Annotations	Cellular Component		Cellular_component Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Phosphatidylserine Binding Molecular_function Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process		Cytolysis Defense Response To Bacterium Pyroptosis
Pathways
Drugs
Diseases
GWAS			Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 21804549 31361310 31959851 30929738 34103634 20860503 32296059 31619474 29273806 28461288) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 27611488 24241537 29273806) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33339817) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 28314753 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 21738480)
Interacting Genes		6 interacting genes: CDK12 GSDMB JMJD6 SUV39H1 TRIM55 TRIM63	17 interacting genes: AGT APP CDK12 CLK1 CWC25 DHRS11 FNDC8 GGNBP2 HIVEP1 IGFBP2 MRM1 MYO19 NLE1 ORM1 PEBP1 SERPINA1 SLFN12
Entrez ID		55106	55876
HPRD ID		08543	17082
Ensembl ID		ENSG00000172123	ENSG00000073605
Uniprot IDs		Q8IYM2	Q8TAX9
PDB IDs			5TIB 5TJ2 5TJ4
Enriched GO Terms of Interacting Partners?
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