ZCWPW1 and VAC14

Number of citations of the paper that reports this interaction (PubMedID 26871637)
172

Data Source:
BioGRID (two hybrid)

		ZCWPW1	VAC14
Description		zinc finger CW-type and PWWP domain containing 1	VAC14 component of PIKFYVE complex
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome	Golgi Membrane Extrinsic Component Of Vacuolar Membrane Endoplasmic Reticulum Cytosol Endosome Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle PAS Complex
	Molecular Function	Zinc Ion Binding Methyl-CpG Binding Methylated Histone Binding	Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Meiosis I Homologous Chromosome Pairing At Meiosis Spermatogenesis Cell Differentiation Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair	Phosphatidylinositol Biosynthetic Process Signal Transduction Positive Regulation Of Kinase Activity
Pathways			Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (MOSTest) ( 32665545) Family history of Alzheimer's disease ( 30617256) Hemoglobin levels ( 32327693) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		4 interacting genes: KMT2E L3MBTL3 MEOX2 VAC14	108 interacting genes: ABHD11 ACSS1 AMT APP ARID5A ASB13 BCL2L1 BHLHE40 C11orf54 C19orf54 C2CD6 C4orf33 CASP1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FIG4 FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KEAP1 KHDC1 KRBOX5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPRYD7 SRPK2 TCEANC TEX37 TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34
Entrez ID		55063	55697
HPRD ID		15706	07660
Ensembl ID		ENSG00000078487	ENSG00000103043
Uniprot IDs		Q9H0M4	Q08AM6
PDB IDs		2E61 2RR4
Enriched GO Terms of Interacting Partners?
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