PPP1R3A and PLN

Number of citations of the paper that reports this interaction (PubMedID 9845327)
8

Data Source:
HPRD (in vitro, in vivo)

		PPP1R3A	PLN
Description		protein phosphatase 1 regulatory subunit 3A	phospholamban
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Integral Component Of Membrane	Mitochondrion Endoplasmic Reticulum Membrane Sarcoplasmic Reticulum Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex
	Molecular Function	Protein Phosphatase 1 Binding Glycogen Binding	Enzyme Inhibitor Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity ATPase Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Notch Signaling Pathway Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways			Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Adult body size ( 32376654) Blood pressure (smoking interaction) ( 25189868) Chronotype ( 30696823) Hand grip strength ( 29691431) Schizophrenia ( 28991256 30285260) Walking pace ( 33128006)	Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 23166209 24952745 19305408 19305409 19587794 29874175) Resting heart rate ( 27798624)
Interacting Genes		8 interacting genes: PLN PPP1CB PPP1CC PPP1R11 PPP1R7 RPS6KA1 UBXN2B VCP	65 interacting genes: ARL13B ASGR2 ATP2A1 ATP2A2 ATP6V0E1 BAP1 BCL2L13 BIK CD53 CLDN7 CLEC2D CPLX4 CREB3 CREB3L1 DMPK DVL3 EDA ELOVL4 FAM209A FKBP8 FNDC9 GJA8 GPR152 GPR37L1 GPX8 HIBADH HSD17B13 KIR2DL3 LDLRAD1 LSMEM2 MFF MFSD5 MGST2 MGST3 MS4A7 MTIF3 MUC1 PLPPR1 PPP1R3A PRKACA RTN3 S100A1 SAR1A SDC3 SIT1 SLC14A2 SLC30A8 SLC34A2 SLC35C2 SLC39A2 SLN SPACA1 SPAG4 STX1A STX2 TMEM106C TMEM179B TMEM205 TMEM31 TMEM45A TMEM45B TMEM52B TMEM79 TMEM86B TMPRSS2
Entrez ID		5506	5350
HPRD ID		02950	01395
Ensembl ID		ENSG00000154415	ENSG00000198523
Uniprot IDs		Q16821	P26678 Q5R352
PDB IDs		5ZQV	1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN 6Y40
Enriched GO Terms of Interacting Partners?
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