STX17 and MSH2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		STX17	MSH2
Description		syntaxin 17	mutS homolog 2
Image
GO Annotations	Cellular Component	Autophagosome Membrane Mitochondrion Lysosomal Membrane Autophagosome Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endomembrane System ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane COPII-coated ER To Golgi Transport Vesicle Smooth Endoplasmic Reticulum Membrane SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Mitochondria-associated Endoplasmic Reticulum Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSalpha Complex MutSbeta Complex
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding	Magnesium Ion Binding Four-way Junction DNA Binding Double-strand/single-strand DNA Junction Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Intracellular Protein Transport Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Fusion Golgi Organization Autophagosome Membrane Docking Protein Localization To Phagophore Assembly Site Vesicle Docking Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Autophagosome Maturation	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair DNA Recombination Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Mitotic Intra-S DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Helicase Activity Protein Localization To Chromatin
Pathways		COPII-mediated vesicle transport	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS		Alopecia areata ( 20596022) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)	Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		23 interacting genes: AURKA BUB1 CDH1 CTNNA1 DLC1 EGFR ERP44 KRAS MAP2K4 MIS18A MLH1 MLH3 MSH2 NRAS ODC1 PTPN12 PTPN2 RB1 SMAD4 SNAP29 SRC STK11 TLR2	49 interacting genes: AKT1 ALK ANXA7 APPBP2 ATR BARD1 BRCA1 CCDC180 CDC14B CDC42 CDKN1A CHEK2 CREBBP DVL1 EPHA2 ESR1 ESR2 EXO1 FBP1 FBP2 FGFR4 GALNT12 GRB7 HDAC6 HRAS HUS1 LEF1 MAX MSH3 MSH6 MYC PCNA PPP3R2 RAD1 RAD9A RPA4 RPP14 SMAD1 SMC1A SMN1 STX17 SUMO2 TDRD7 TK1 TREX1 TRIM29 USP10 XPA ZNF510
Entrez ID		55014	4436
HPRD ID		05013	00389
Ensembl ID		ENSG00000136874	ENSG00000095002
Uniprot IDs		P56962	A0A2R8Y6P0 P43246
PDB IDs		4WY4 7BV4 7BV6	2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
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