WBP1L and EPN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		WBP1L	EPN2
Description		WW domain binding protein 1 like	epsin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin Coat Of Endocytic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Clathrin Binding Cadherin Binding
	Biological Process		Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Sprouting Angiogenesis
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Carotid plaque burden ( 28282560) Chloride levels ( 29403010) Coronary artery disease ( 32469254) Diastolic blood pressure (long-term average) ( 28348047) Estimated glomerular filtration rate ( 31152163 31015462) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 30487518) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean arterial pressure ( 30487518) Mean arterial pressure (long-term average) ( 28348047) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Prostate cancer ( 23535732) Pulse pressure ( 30487518) Red blood cell count ( 32888494) Schizophrenia ( 28991256 25056061 29483656 23974872) Sodium levels ( 29403010) Systolic blood pressure ( 30487518) Systolic blood pressure (long-term average) ( 28348047) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		6 interacting genes: ABHD16A CNNM2 DPCD EPN2 LIG4 SGTA	40 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 SMAD1 SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG
Entrez ID		54838	22905
HPRD ID		12567	06271
Ensembl ID		ENSG00000166272	ENSG00000072134
Uniprot IDs		Q9NX94	O95208
PDB IDs
Enriched GO Terms of Interacting Partners?
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