TRPM7 and PLCB2

Number of citations of the paper that reports this interaction (PubMedID 11941371)
187

Data Source:
HPRD (in vitro, two hybrid)

		TRPM7	PLCB2
Description		transient receptor potential cation channel subfamily M member 7	phospholipase C beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Plasma Membrane Integral Component Of Plasma Membrane	Cytosol
	Molecular Function	Actin Binding Cation Channel Activity Calcium Channel Activity ATP Binding Myosin Binding Metal Ion Binding Protein Serine Kinase Activity	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding
	Biological Process	Calcium Ion Transport Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Protein Autophosphorylation Protein Tetramerization Necroptotic Process Calcium Ion Transmembrane Transport Divalent Inorganic Cation Homeostasis Cation Transmembrane Transport	Phospholipid Metabolic Process G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Lipid Catabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste
Pathways		TRP channels	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester 1,4-Dithiothreitol
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Calcium levels ( 29403010) Chronic obstructive pulmonary disease ( 30804561) Electrocardiographic traits (multivariate) ( 32602732) Household income (MTAG) ( 31844048) Pulse pressure ( 27841878) QT interval ( 24952745) Systolic blood pressure ( 27841878)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: ANXA1 EEF2 H3-4 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6	18 interacting genes: - FAM98B GCHFR GNAQ MAP2K3 MAP2K6 MTAP NEK2 PDIA3 PKD1L1 SLC9A3R1 SNCA SOCS5 SPP1 THBS1 TRIB3 TRPC3 TRPM7
Entrez ID		54822	5330
HPRD ID		10418	04985
Ensembl ID		ENSG00000092439	ENSG00000137841
Uniprot IDs		A0A024R5V1 H0YLN8 Q96QT4	Q00722 Q59F77 Q9BVT6
PDB IDs			2FJU 2ZKM
Enriched GO Terms of Interacting Partners?
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