TOMM7 and DHFR

		TOMM7	DHFR
Description		translocase of outer mitochondrial membrane 7	dihydrofolate reductase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Integral Component Of Membrane	Mitochondrion Cytosol
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity	Translation Repressor Activity, MRNA Regulatory Element Binding MRNA Binding Dihydrofolate Reductase Activity Folic Acid Binding NADP Binding Methotrexate Binding NADPH Binding Sequence-specific MRNA Binding
	Biological Process	Protein Targeting To Mitochondrion Protein Import Into Mitochondrial Matrix Regulation Of Protein Stability Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Protein Targeting To Mitochondrion	Glycine Biosynthetic Process Tetrahydrobiopterin Biosynthetic Process One-carbon Metabolic Process Negative Regulation Of Translation Axon Regeneration Response To Methotrexate Dihydrofolate Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Removal Of Superoxide Radicals
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Metabolism of folate and pterines G1/S-Specific Transcription
Drugs			NADH Pyrimethamine Methotrexate Pemetrexed Gentamicin Proguanil Trimetrexate 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]Quinazoline 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine 2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Sri-9662 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium Sri-9439 Nicotinamide adenine dinucleotide phosphate Piritrexim Biopterin 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Iclaprim Pralatrexate 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
Diseases
GWAS		Asthma ( 31959851 30929738 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness ( 32963231) Glomerular filtration rate (creatinine) ( 26831199) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Shingles ( 25297839) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: DHFR ITGB8 PEX5 TOMM22 TOMM40	17 interacting genes: - AMFR ASGR1 CDC42 COPS8 CRHBP DTYMK EXOC4 FKBP1A GKAP1 HSPD1 MDM2 RHOQ THBS1 TOMM20 TOMM7 TP53
Entrez ID		54543	1719
HPRD ID		16266	00519
Ensembl ID		ENSG00000196683	ENSG00000228716
Uniprot IDs		Q75MR5 Q9P0U1	B0YJ76 B4DM58 P00374
PDB IDs		7CK6	1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3B 2W3M 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW 3GI2 3GYF 3L3R 3N0H 3NTZ 3NU0 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZD 3OAF 3S3V 3S7A 4DDR 4G95 4KAK 4KBN 4KD7 4KEB 4KFJ 4M6J 4M6K 4M6L 4QHV 4QJC 5HPB 5HQY 5HQZ 5HSR 5HSU 5HT4 5HT5 5HUI 5HVB 5HVE 6A7C 6A7E 6DAV 6DE4 6VCJ
Enriched GO Terms of Interacting Partners?
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