RIN2 and BIN1

Number of citations of the paper that reports this interaction (PubMedID 12972505)
65

Data Source:
HPRD (in vitro)

		RIN2	BIN1
Description		Ras and Rab interactor 2	bridging integrator 1
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Lipid Tube
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Regulator Activity	Protease Binding Protein Binding Phospholipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Tau Protein Binding Actin Filament Binding Chaperone Binding RNA Polymerase Binding
	Biological Process	Endocytosis Small GTPase Mediated Signal Transduction Positive Regulation Of Endothelial Cell Migration Regulation Of Catalytic Activity Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Nucleus Localization Regulation Of Cell Cycle Lipid Tube Assembly Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		RAB GEFs exchange GTP for GDP on RABs	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 20889312) Bone mineral density (total hip) ( 29883787) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol ( 31170924) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494 27863252) Response to valproic acid in genetic generalized epilepsy ( 32308125) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398) Verbal declarative memory ( 25648963) Weight ( 28552196)	Alzheimer's disease ( 22832961 21460840 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 21390209 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis and Alzheimer's disease ( 22005930) Systemic lupus erythematosus ( 24871463)
Interacting Genes		7 interacting genes: BIN1 CDKN2A EGFR ERBB2 RAB5A RAB5B RAB5C	46 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3
Entrez ID		54453	274
HPRD ID		15249	03150
Ensembl ID		ENSG00000132669	ENSG00000136717
Uniprot IDs		A1A4T0 Q8WYP3	A0A024RAE9 A0A024RAF0 A0A024RAF1 A0A024RAF6 A0A024RAG8 A0A024RAG9 A0A024RAI4 A0A024RAI5 A0A024RAI6 A0A024RAJ2 A0A024RAJ3 B7Z2Z2 B7Z6Y2 O00499 Q9BTH3
PDB IDs			1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?