POLD1 and POLD4

Number of citations of the paper that reports this interaction (PubMedID 26496610)
430

Data Source:
BioGRID (affinity chromatography technology, pull down, pull down)

		POLD1	POLD4
Description		DNA polymerase delta 1, catalytic subunit	DNA polymerase delta 4, accessory subunit
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex	Nucleoplasm Delta DNA Polymerase Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Enzyme Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-dependent DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling Response To UV Cellular Response To UV DNA Replication Proofreading Fatty Acid Homeostasis Error-free Translesion Synthesis DNA Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		23 interacting genes: ADAMTSL4 ASXL1 ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 LASP1 MCPH1 PCNA POLA1 POLD2 POLD3 POLD4 SUMO2 TREX2 TRIM55 WRNIP1 XRCC5 YPEL3	9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1
Entrez ID		5424	57804
HPRD ID		08882	17873
Ensembl ID		ENSG00000062822	ENSG00000175482
Uniprot IDs		A0A024R4F4 A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0	A0A024R5D7 Q6NSD7 Q9HCU8
PDB IDs		6S1M 6S1N 6S1O 6TNY 6TNZ	6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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