ACP5 and TNFSF10

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ACP5	TNFSF10
Description		acid phosphatase 5, tartrate resistant	TNF superfamily member 10
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GO Annotations	Cellular Component	Lysosome Cytosol Integral Component Of Membrane	Extracellular Region Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Acid Phosphatase Activity Ferrous Iron Binding Ferric Iron Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Identical Protein Binding TRAIL Binding
	Biological Process	Dephosphorylation Response To Lipopolysaccharide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Superoxide Anion Generation Response To Cytokine Negative Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Negative Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Bone Morphogenesis	Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Male Gonad Development Response To Insulin Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Vitamin B2 (riboflavin) metabolism	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Multiple sclerosis (severity) ( 19010793)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Breast cancer ( 28171663) Breast cancer (estrogen-receptor negative) ( 28171663) Carotid plaque burden ( 28282560) Cocaine dependence ( 31212010) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Liver volume ( 34128465) Monocyte percentage of white cells ( 27863252) TRAIL levels ( 27989323) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		11 interacting genes: EGR2 GPC4 MAPK9 PDCD5 PPP2CB RPA2 SLC35F6 SNRNP40 SPP1 TNFSF10 ZBTB16	9 interacting genes: ACP5 CASP3 RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17
Entrez ID		54	8743
HPRD ID		01374	04670
Ensembl ID		ENSG00000102575	ENSG00000121858
Uniprot IDs		A0A024R7F8 P13686	P50591 Q6IBA9
PDB IDs		1WAR 2BQ8	1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
Enriched GO Terms of Interacting Partners?
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