PLCB3 and KRIT1

Number of citations of the paper that reports this interaction (PubMedID 12821674)
6

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PLCB3	KRIT1
Description		phospholipase C beta 3	KRIT1 ankyrin repeat containing
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GO Annotations	Cellular Component	Nucleus Cytosol Membrane Protein-containing Complex Postsynaptic Cytosol	Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding GTPase Regulator Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Small GTPase Mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Cell Redox Homeostasis Regulation Of Catalytic Activity Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Type 2 diabetes (adjusted for BMI) ( 29632382) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Coffee consumption ( 31046077) Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		13 interacting genes: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7	8 interacting genes: CDK6 FAS ITGB1BP1 PLCB3 RAP1A RGS4 TRPV4 UBE2K
Entrez ID		5331	889
HPRD ID		02577	05020
Ensembl ID		ENSG00000149782	ENSG00000001631
Uniprot IDs		Q01970	A4D1F7 O00522
PDB IDs		3OHM 4GNK 4QJ3 4QJ4 4QJ5	3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF 4TKN 5D68 6OQ3 6OQ4 6UZK
Enriched GO Terms of Interacting Partners?
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