PLA2G2A and PLA2R1

Number of citations of the paper that reports this interaction (PubMedID 7721806)
43

Data Source:
HPRD (in vitro)

		PLA2G2A	PLA2R1
Description		phospholipase A2 group IIA	phospholipase A2 receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Extracellular Exosome	Extracellular Region Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity	Carbohydrate Binding Signaling Receptor Activity Phospholipase Binding
	Biological Process	Phospholipid Metabolic Process Inflammatory Response Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Cytolysis Low-density Lipoprotein Particle Remodeling Intestinal Stem Cell Homeostasis Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidic Acid Metabolic Process Arachidonic Acid Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Neutrophil Activation	Positive Regulation Of Cytokine Production Receptor-mediated Endocytosis Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Arachidonic Acid Secretion Replicative Senescence Oxidative Stress-induced Premature Senescence Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Arachidonic Acid Secretion Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Antimicrobial peptides	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs		Indomethacin Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid Lauric acid (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid Elaidamide (2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate KH064 Suramin Varespladib methyl
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Immunoglobulin light chain (AL) amyloidosis ( 28025584)	Bilirubin levels ( 20639394) Blood protein levels ( 30072576 29875488) Crohn's disease ( 26192919) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 26192919) Membranous nephropathy ( 32231244 27333618) Platelet count ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278) Tourette syndrome ( 30818990) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		27 interacting genes: ALOX12 BAG6 CEP70 CRMP1 DCN ITGAV ITGB3 JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 SUZ12 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM	3 interacting genes: PLA2G10 PLA2G2A SCN2A
Entrez ID		5320	22925
HPRD ID		01397	09222
Ensembl ID		ENSG00000188257	ENSG00000153246
Uniprot IDs		A0A024RA96 P14555	B7ZML4 Q13018
PDB IDs		1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I 5G3N	6JLI
Enriched GO Terms of Interacting Partners?
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