ABCB4 and PIGY

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ABCB4	PIGY
Description		ATP binding cassette subfamily B member 4	phosphatidylinositol glycan anchor biosynthesis class Y
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Integral Component Of Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Phospholipid Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylethanolamine Flippase Activity Ceramide Floppase Activity ABC-type Transporter Activity	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	Lipid Metabolic Process Positive Regulation Of Cholesterol Transport Bile Acid Secretion Xenobiotic Transport Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport	GPI Anchor Biosynthetic Process
Pathways		PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes PFIC3, ICP3 and GBD1	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Epithelial ovarian cancer ( 25134534) Gallbladder cancer ( 28274756) Gallstone disease ( 30504769) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels ( 30275531)	Bipolar disorder ( 22925353) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: HAX1 PIGY PRKAR2B TESK1	5 interacting genes: ABCB4 ERG28 FBXO7 PIGA TMEM72
Entrez ID		5244	84992
HPRD ID		01371	17492
Ensembl ID		ENSG00000005471	ENSG00000255072
Uniprot IDs		P21439	Q3MUY2
PDB IDs		6S7P
Enriched GO Terms of Interacting Partners?
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