ATP5PF and KCNK5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ATP5PF	KCNK5
Description		ATP synthase peripheral stalk subunit F6	potassium two pore domain channel subfamily K member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Proton-transporting ATP Synthase Complex, Coupling Factor F(o) Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Cell Surface	Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Protein-containing Complex Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism	Voltage-gated Ion Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Leak Channel Activity
	Biological Process	Positive Regulation Of Heart Rate Response To Muscle Activity Substantia Nigra Development Negative Regulation Of Prostaglandin Secretion Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Blood Pressure Negative Regulation Of Arachidonic Acid Secretion	Potassium Ion Transport Excretion Stabilization Of Membrane Potential Regulation Of Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation	Phase 4 - resting membrane potential
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Eating disorders ( 23568457) Fasting plasma glucose ( 32682390) HDL cholesterol levels ( 32203549) Hypertension in type 2 diabetes ( 33276381) Kidney stones ( 31729369) Migraine ( 27322543) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Social communication problems ( 24564958) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urolithiasis ( 30975718)
Interacting Genes		18 interacting genes: ABHD16A ATP5F1B BCL2L2 INPP5K KCNK5 MALL MAPK6 MIEF1 MIEF2 MOSPD3 NDRG4 PHOSPHO2 PLP2 PTPN9 REEP6 RPS6KA3 SFT2D2 SIGLEC12	30 interacting genes: ADIPOQ AGTRAP APP AQP1 ATP5PF BNIP2 CMTM5 COMT CYB5B FRAT1 GJB2 IGFBP5 LHFPL5 MAN2B2 ORMDL3 SLC66A2 SMCO4 STRIT1 TM4SF4 TMEM128 TMEM14A TMEM176A TMEM218 TMEM54 TMEM60 TNFRSF10C TSPAN33 VAMP3 YIF1A YIPF6
Entrez ID		522	8645
HPRD ID		04399	04604
Ensembl ID		ENSG00000154723	ENSG00000164626
Uniprot IDs		P18859 Q6IB54 Q6NZ59	A0A024RD32 A0A0B6VPR3 O95279
PDB IDs
Enriched GO Terms of Interacting Partners?
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