PFN2 and SEPTIN5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	SEPTIN5
Description		profilin 2	septin 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome	Plasma Membrane Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity	GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Synaptic Vesicle Targeting Regulation Of Exocytosis Adult Behavior Cellular Protein Localization Social Behavior Cytoskeleton-dependent Cytokinesis Regulation Of Synaptic Vesicle Exocytosis
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	24 interacting genes: APP CDK5R1 DDIT4L KAT7 KIDINS220 LSM8 MAGEA2 MAGEA2B MAPK6 MYOG PFN2 PLEKHF2 PRKN PRODH SEPTIN1 SEPTIN11 SEPTIN12 SEPTIN2 SEPTIN4 SEPTIN7 SEPTIN8 SPG21 STX1A STX4
Entrez ID		5217	5413
HPRD ID		01451	04100
Ensembl ID		ENSG00000070087	ENSG00000184702
Uniprot IDs		P35080	Q99719 X5DNA9
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?
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