PFDN2 and MAP3K3

Number of citations of the paper that reports this interaction (PubMedID 14743216)
321

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PFDN2	MAP3K3
Description		prefoldin subunit 2	mitogen-activated protein kinase kinase kinase 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex	Cytosol
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Folding Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Amyloid Fibril Formation	MAPK Cascade Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Cellular Senescence
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Interleukin-1 signaling
Drugs			Fostamatinib
Diseases
GWAS			Adult body size ( 32376654) Height ( 21998595 28552196 22021425 25429064 18391951) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: DBI ERBB3 MAP3K3 PFDN1 PFDN4 RGS4 SNCA VBP1 ZNF726	42 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16
Entrez ID		5202	4215
HPRD ID		09658	03965
Ensembl ID		ENSG00000143256	ENSG00000198909
Uniprot IDs		B1AQP2 Q9UHV9	J3KRN4 Q96HN9 Q99759
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	2C60 2JRH 2O2V 2PPH 4Y5O 4YL6
Enriched GO Terms of Interacting Partners?
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