PEX14 and PEX5

Number of citations of the paper that reports this interaction (PubMedID 11865044)
54

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)
HPRD (in vivo, in vitro)

		PEX14	PEX5
Description		peroxisomal biogenesis factor 14	peroxisomal biogenesis factor 5
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Cytosol Membrane Integral Component Of Membrane Protein-containing Complex Peroxisomal Importomer Complex	Cytoplasm Peroxisome Peroxisomal Membrane Golgi Apparatus Cytosol Membrane Protein-containing Complex
	Molecular Function	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Identical Protein Binding Protein N-terminus Binding Beta-tubulin Binding	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein N-terminus Binding Protein Sequestering Activity
	Biological Process	Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Negative Regulation Of Protein Binding Microtubule Anchoring Peroxisome Transport Along Microtubule Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Transcription, DNA-templated Protein-containing Complex Assembly	Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Protein-containing Complex Assembly Protein Import Into Peroxisome Membrane
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import	Pexophagy
Drugs
Diseases
GWAS		Asthma ( 34103634 27182965 32296059) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)	IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)
Interacting Genes		15 interacting genes: CENPK COPS4 GET3 HDAC1 MARF1 MED8 MTNR1A NFE2 OGT PEX19 PEX26 PEX5 PEX7 SMARCC2 ZHX1	77 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 NUFIP2 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772
Entrez ID		5195	5830
HPRD ID		03477	02684
Ensembl ID		ENSG00000142655	ENSG00000139197
Uniprot IDs		O75381	A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542
PDB IDs		2W84 2W85 4BXU	1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO
Enriched GO Terms of Interacting Partners?
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