RTEL1 and RAE1

		RTEL1	RAE1
Description		regulator of telomere elongation helicase 1	ribonucleic acid export 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm	Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Mitotic Spindle Pole
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding DNA Polymerase Binding	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding
	Biological Process	Telomere Maintenance Strand Displacement DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Replication Fork Processing Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Telomere Maintenance In Response To DNA Damage Negative Regulation Of DNA Recombination Telomeric Loop Disassembly Mitotic Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomere Capping Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Telomeric Loop Disassembly	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Cell Cycle Cell Division Regulation Of Mitotic Spindle Organization Cellular Response To Organic Cyclic Compound
Pathways		Telomere Extension By Telomerase Cytosolic iron-sulfur cluster assembly Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		Adult diffuse glioma (IDH wildtype) ( 32386320) Adult diffuse glioma (TERT mutation only) ( 32386320) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Anorectal malformation ( 31136621) Asthma ( 31361310 30929738 32296059 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Crohn's disease ( 28067908 21102463) Cutaneous malignant melanoma ( 32341527 26237428) Dental caries ( 23259602) Eczema ( 31361310) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 30714141 28346443 21531791 22886559 29743610 19578367) Glioma (high-grade) ( 24908248 19578366) Idiopathic pulmonary fibrosis ( 31710517) Inflammatory bowel disease ( 28067908) Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527) Non-glioblastoma glioma ( 28346443 29743610) Plateletcrit ( 32888494 27863252) Prostate cancer ( 23535732) Refractive error ( 32231278) Telomere length ( 29151059) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		1 interacting genes: RAE1	17 interacting genes: AQP7 BDKRB1 BUB1 CASS4 CREBRF DDX24 FZD8 HPCA HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 PCK1 RBM38 RTEL1
Entrez ID		51750	8480
HPRD ID		15281	11939
Ensembl ID		ENSG00000258366	ENSG00000101146
Uniprot IDs		Q9NZ71 R4IXY3	P78406
PDB IDs			3MMY 4OWR
Enriched GO Terms of Interacting Partners?
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