SRRT and HTR6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		SRRT	HTR6
Description		serrate, RNA effector molecule	5-hydroxytryptamine receptor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Body Protein-containing Complex Ribonucleoprotein Complex	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	DNA Binding RNA Binding Protein Binding Protein-macromolecule Adaptor Activity MRNA Cap Binding Complex Binding	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Regulation Of Transcription, DNA-templated MRNA Processing Primary MiRNA Processing Response To Arsenic-containing Substance Positive Regulation Of Neurogenesis Neuronal Stem Cell Population Maintenance	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		RNA polymerase II transcribes snRNA genes mRNA Splicing - Major Pathway	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Hemoglobin levels ( 32327693) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Resting heart rate ( 27798624) RR interval (heart rate) ( 30679814)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		16 interacting genes: APP CACNA1C CHD3 CSNK2A1 GEMIN4 GIT1 HNRNPK HSPA8 HTR6 IMMT LINC00624 SNRPF STAT3 SUMO2 VAV2 VIM	32 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CD160 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		51593	3362
HPRD ID		10665	03066
Ensembl ID		ENSG00000087087	ENSG00000158748
Uniprot IDs		Q9BXP5	P50406
PDB IDs		5OO6 6F7J 6F7P 6F7S 6F8D
Enriched GO Terms of Interacting Partners?
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