TRIM33 and VTCN1

		TRIM33	VTCN1
Description		tripartite motif containing 33	V-set domain containing T cell activation inhibitor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Co-SMAD Binding R-SMAD Binding	Molecular_function Signaling Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transcription, DNA-templated	Response To Protozoan Regulation Of Cytokine Production Adaptive Immune Response Positive Regulation Of Interleukin-2 Production Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Autism ( 24189344) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)	Arthritis (juvenile idiopathic) ( 19116933) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		13 interacting genes: CHD1L CTNNB1 ERG H3C1 NLGN3 RASGRP1 SMAD3 TRIM24 UBE2D2 UBE2D3 UBE2E1 UBE2N VTCN1	2 interacting genes: BTLA TRIM33
Entrez ID		51592	79679
HPRD ID		10423	06429
Ensembl ID		ENSG00000197323	ENSG00000134258
Uniprot IDs		B3KN30 Q9UPN9	Q7Z7D3
PDB IDs		3U5M 3U5N 3U5O 3U5P 5MR8	4GOS
Enriched GO Terms of Interacting Partners?
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