PIAS4 and TOP2B

Number of citations of the paper that reports this interaction (PubMedID 33188014)
7

Data Source:
BioGRID (enzymatic study)

		PIAS4	TOP2B
Description		protein inhibitor of activated STAT 4	DNA topoisomerase II beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex	Heterochromatin Nucleus Nucleoplasm Nucleolus Cytosol Ribonucleoprotein Complex
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity	DNA Binding Chromatin Binding DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding ATP Binding Protein C-terminus Binding Enzyme Binding Histone Deacetylase Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Neuron Migration DNA Topological Change Axonogenesis Forebrain Development Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Pathways		Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	SUMOylation of DNA replication proteins
Drugs			Dexrazoxane Daunorubicin Etoposide Dactinomycin Phosphoaminophosphonic Acid-Adenylate Ester Amonafide Technetium Tc-99m ciprofloxacin ZEN-012 Becatecarin Declopramide 3'-THIO-THYMIDINE-5'-PHOSPHATE
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)	Chronic obstructive pulmonary disease ( 30804561)
Interacting Genes		88 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LCE1D LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RIF1 RPA2 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP1 TOP2A TOP2B TP53 TRIM27 TRIM32 TRIM38 UBE2I UBE2K VHL VIM ZBTB34 ZHX1 ZNF512B ZW10	19 interacting genes: CD3E CSNK2B ERG HDAC1 HDAC2 LAMTOR5 MAPK3 PIAS4 RANBP2 RARA RNF4 SUMO1 SUMO2 TOP2A TOPBP1 TP53 UBE2I XPO1 XRCC5
Entrez ID		51588	7155
HPRD ID		06910	00537
Ensembl ID		ENSG00000105229	ENSG00000077097
Uniprot IDs		B3KMR4 Q8N2W9	Q02880 Q59H80
PDB IDs			3QX3 4G0U 4G0V 4G0W 4J3N 5GWI 5GWJ 5ZAD 5ZEN 5ZQF 5ZRF
Enriched GO Terms of Interacting Partners?
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