ISYNA1 and TRAF4

Number of citations of the paper that reports this interaction (PubMedID 25910212)
170

Data Source:
BioGRID (two hybrid)

		ISYNA1	TRAF4
Description		inositol-3-phosphate synthase 1	TNF receptor associated factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Perinuclear Region Of Cytoplasm Plasma Membrane Signaling Receptor Complex
	Molecular Function	Inositol-3-phosphate Synthase Activity Protein Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding WW Domain Binding
	Biological Process	Inositol Biosynthetic Process Phospholipid Biosynthetic Process	Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange By Respiratory System Respiratory Tube Development Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade
Pathways		Synthesis of IP2, IP, and Ins in the cytosol
Drugs		2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate 2-Deoxy-Glucitol-6-Phosphate Glycerin
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Blood metabolite levels ( 24816252) Breast cancer ( 23535729) Heel bone mineral density ( 30598549)
Interacting Genes		6 interacting genes: DUSP14 GATAD2A OGT POT1 PPP2CA TRAF4	133 interacting genes: ABI3 ALKBH4 ATOX1 BACH2 BAHD1 BANP BCKDK BCL6B BEGAIN BEX3 BYSL C19orf54 CALCOCO2 CBL CBLC CCHCR1 CENPE CEP85 CHEK1 CHUK DISC1 DNM2 DPEP2NB DTX3 EXOC7 EYA2 EZHIP FAM214B FAM90A1 FAT1 FBXL18 FRS3 FTH1 GOLGA2 GOLGA6A GOLGA6L9 GORASP1 GORASP2 GPRASP1 HEY2 HGS HMG20A HOMEZ HOXA1 HOXB5 IRAK1 ISYNA1 KANK2 KANSL1 KDM1A KRT31 KRT36 KRT40 LENG8 LNX1 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NOS1AP NPAS2 NTRK1 NUDT16L1 OGT PCSK5 PDE4DIP PHLDA1 PICK1 PKD1P1 PLAGL2 PLEKHA7 PLSCR1 POLR2J POLR2J3 PSMC3 QARS1 RAD54L2 RBPMS REXO1L6P RNF114 RNF144B RNF4 RPS6KB1 SF3B4 SIGLEC7 SLC9A3R2 SMURF1 SMURF2 SNRPB SORBS2 SPDL1 SUMO1 TARBP2 TAX1BP1 TBC1D7 TBC1D8 TFAP4 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM27 TRIM37 TSGA10IP TYK2 UBE2D1 UBE2I UBL4A UBL4B USP7 VPS52 WBP11 WWP1 WWP2 ZBTB16 ZBTB26 ZC3H12C ZMYM5 ZNF177 ZNF275 ZNF3 ZNF512B ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF784 ZNF835 ZRANB1
Entrez ID		51477	9618
HPRD ID		17163	03915
Ensembl ID		ENSG00000105655	ENSG00000076604
Uniprot IDs		A0A140VK73 Q9NPH2	A0A024QZ19 A0A024QZ59 Q9BUZ4
PDB IDs			2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?
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