PCYOX1 and CYP26B1

		PCYOX1	CYP26B1
Description		prenylcysteine oxidase 1	cytochrome P450 family 26 subfamily B member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Plasma Membrane Very-low-density Lipoprotein Particle Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Membrane
	Molecular Function	Prenylcysteine Oxidase Activity Protein Binding	Retinoic Acid Binding Monooxygenase Activity Iron Ion Binding Protein Binding Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding
	Biological Process	Prenylated Protein Catabolic Process Prenylcysteine Catabolic Process Chloride Transmembrane Transport	Cell Fate Determination Establishment Of T Cell Polarity Kidney Development Vitamin Metabolic Process Xenobiotic Metabolic Process Inflammatory Response Male Meiotic Nuclear Division Spermatogenesis Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Sterol Metabolic Process Embryonic Limb Morphogenesis Response To Vitamin A Retinoic Acid Catabolic Process Retinoic Acid Metabolic Process Tongue Morphogenesis Regulation Of T Cell Differentiation Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Bone Morphogenesis Establishment Of Skin Barrier Cornification Cellular Response To Retinoic Acid Positive Regulation Of Tongue Muscle Cell Differentiation
Pathways			Vitamins RA biosynthesis pathway Defective CYP26B1 causes RHFCA
Drugs			Tretinoin
Diseases
GWAS		Acne (severe) ( 24927181) Chronotype ( 30696823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Male-pattern baldness ( 28196072) Morning person ( 30696823)	Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Heel bone mineral density ( 30598549) Height ( 31562340) IgA levels ( 28628107) Malaria ( 31844061) Mitochondrial heteroplasmy measurement ( 33731350) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Schizophrenia ( 25056061) Serum metabolite levels ( 33031748)
Interacting Genes		4 interacting genes: CYP26B1 HOXA1 MPHOSPH10 OGT	5 interacting genes: CEBPG GMCL1 GTF2H2 NEDD4L PCYOX1
Entrez ID		51449	56603
HPRD ID		11422	05550
Ensembl ID		ENSG00000116005	ENSG00000003137
Uniprot IDs		Q9UHG3	E7ER08 Q9NR63
PDB IDs
Enriched GO Terms of Interacting Partners?
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