PDE3B and ANKRA2

Number of citations of the paper that reports this interaction (PubMedID 22649097)
15

Data Source:
BioGRID (unspecified method)

		PDE3B	ANKRA2
Description		phosphodiesterase 3B	ankyrin repeat family A member 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Guanyl-nucleotide Exchange Factor Complex	Nucleus Cytosol Cytoskeleton Membrane Protein-containing Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Protein Kinase B Binding Metal Ion Binding	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Angiogenesis Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Angiogenesis Cellular Response To Insulin Stimulus Negative Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Lipid Catabolic Process	Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly
Pathways		PDE3B signalling PDE3B signalling G alpha (s) signalling events
Drugs		Caffeine Caffeine Amrinone 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Adiponectin levels ( 31178129) Bipolar disorder ( 31043756) HDL cholesterol ( 30275531) High density lipoprotein cholesterol levels ( 29083408) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum 25-Hydroxyvitamin D levels ( 31841498) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Monobrow thickness ( 26926045)
Interacting Genes		7 interacting genes: AKT1 ANKRA2 HPGDS LNX1 PRKACA YWHAB YWHAQ	14 interacting genes: ABL1 APP CDKN2A F2RL1 HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX7 SAMD4A TSHZ3
Entrez ID		5140	57763
HPRD ID		03626	12044
Ensembl ID		ENSG00000152270	ENSG00000164331
Uniprot IDs		A7E2E5 Q13370	A0A024RAN7 Q9H9E1
PDB IDs		1SO2 1SOJ	3SO8 3V2O 3V2X 3V31 4LG6 4QQI
Enriched GO Terms of Interacting Partners?
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