PDE2A and RPS6KA4

		PDE2A	RPS6KA4
Description		phosphodiesterase 2A	ribosomal protein S6 kinase A4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Zinc Ion Binding CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Protein Homodimerization Activity 3',5'-cyclic-GMP Phosphodiesterase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CAMP-mediated Signaling CGMP-mediated Signaling Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine	Negative Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Histone Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway
Pathways		cGMP effects G alpha (s) signalling events	Recycling pathway of L1
Drugs		Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil	Flavin mononucleotide
Diseases
GWAS		Household income (MTAG) ( 31844048) Optic nerve measurement (cup area) ( 20395239) Rheumatoid arthritis ( 22446963)	Cervical high-risk human papilloma virus infection ( 33225922) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Leprosy ( 22019778) Offspring birth weight ( 31043758) Primary biliary cholangitis ( 21399635) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Serum uric acid levels ( 32514006)
Interacting Genes		12 interacting genes: ANAPC15 CHEK1 FAM168A FCHSD2 FOLR1 GLS2 HSD17B6 LRP5 NDUFV1 RPS3 RPS6KA4 SPAG7	10 interacting genes: ATF1 CREB1 FOS HMGN1 MAP2K1 MAPK1 MAPK14 MAPK3 NEDD4 PDE2A
Entrez ID		5138	8986
HPRD ID		04041	04677
Ensembl ID		ENSG00000186642	ENSG00000162302
Uniprot IDs		O00408 Q8IW54	A0PJF8 B4DPV1 E9PJN1 O75676
PDB IDs		1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ
Enriched GO Terms of Interacting Partners?
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