SNX7 and POLR2L

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SNX7	POLR2L
Description		sorting nexin 7	RNA polymerase II, I and III subunit L
Image
GO Annotations	Cellular Component	Cytoplasmic Vesicle Membrane	Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex RNA Polymerase I Complex Cytosol
	Molecular Function	Protein Binding Phosphatidylinositol Binding	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding
	Biological Process	Protein Transport	Regulation Of Transcription By RNA Polymerase I Transcription By RNA Polymerase I Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III
Pathways			Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Copper levels ( 26025379) Daytime nap ( 33568662) Dental caries ( 23259602) Disease progression in age-related macular degeneration ( 29346644) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Insulin-related traits (multivariate analysis) ( 32002517) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Methadone dose in opioid dependence ( 28115739) Night sleep phenotypes ( 27126917) Proinsulin levels ( 21873549) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097 31123309)	Pulse pressure ( 30578418)
Interacting Genes		10 interacting genes: ABI2 BIRC3 HGS HMOX2 MAGEA11 MESD POLR2L SNX4 TBC1D21 TEX11	29 interacting genes: ACSL6 AGR2 BANP CCDC85B CCN3 CHEK2 COIL EXOSC5 FAM217B L3MBTL3 NACC1 NFKBIB PHC2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2G POLR2H PSMA6 REL RPAP1 SNX7 SPAG5 THAP1 TP53BP2 TRIP13 ZBTB14
Entrez ID		51375	5441
HPRD ID		15416	01155
Ensembl ID		ENSG00000162627	ENSG00000177700
Uniprot IDs		B4DP69 E9PNL2 Q9UNH6	P62875
PDB IDs		3IQ2	5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 7A6H 7AE1 7AE3 7AEA 7AST
Enriched GO Terms of Interacting Partners?
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