FZR1 and RASSF1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
52

Data Source:
BioGRID (fluorescent resonance energy transfer)

		FZR1	RASSF1
Description		fizzy and cell division cycle 20 related 1	Ras association domain family member 1
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Microtubule Cytoskeleton
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Ubiquitin Ligase Activator Activity	Protein Binding Zinc Ion Binding
	Biological Process	DNA Repair Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Cell Population Proliferation Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Division Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Negative Regulation Of Cell Aging Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process	Cell Cycle Signal Transduction Ras Protein Signal Transduction Regulation Of Cell Cycle Regulation Of Microtubule Cytoskeleton Organization
Pathways		Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Red cell distribution width ( 32888494)	Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		87 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC5 ANAPC7 ARNT AURKA BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RBBP8 SASS6 SENP2 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TEAD2 TERT THRSP TTF2 UBE2D1 UBE2D3 UBE2K UHRF1	73 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BANF1 BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LARS2 LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PFDN5 PRKDC RAF1 RASSF5 RELA RHOA RHOU SMARCA4 STK11 STK4 SUV39H1 SUV39H2 TEAD2 TERT TMEM115 TMEM158 TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA
Entrez ID		51343	11186
HPRD ID		04687	05470
Ensembl ID		ENSG00000105325	ENSG00000068028
Uniprot IDs		Q9UM11	Q9NS23
PDB IDs		4UI9 5L9T 5L9U	2KZU
Enriched GO Terms of Interacting Partners?
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